作者
Jérémy Bellien, Caroline Fréguin-Bouilland, Robinson Joannidès, Mélanie Hanoy, Isabelle Rémy-Jouet, Christelle Monteil, Michèle Iacob, Laurent Martin, Sylvanie Renet, Cathy Vendeville, Michel Godin, Christian Thuillez, Frank Le Roy
发表日期
2014/2/1
期刊
Nephrology Dialysis Transplantation
卷号
29
期号
2
页码范围
414-422
出版商
Oxford University Press
简介
Background
Middle molecular weight uraemic toxins are considered to play an important role in vascular dysfunction and cardiovascular outcomes in end-stage renal disease (ESRD) patients. Recent dialysis techniques based on convection, specifically high-efficiency on-line haemodiafiltration (HDF), enhance the removal of middle molecular weight toxins and reduce all-cause mortality in haemodialysis (HD) patients. However, the mechanisms of these improved outcomes remain to be established.
Methods
This prospective study randomly assigned 42 ESRD patients to switch from high-flux HD to high-efficiency on-line HDF (n = 22) or to continue HD (n = 20). Brachial artery endothelium-dependent flow-mediated dilatation, central pulse pressure, carotid artery intima-media thickness (IMT), internal diastolic diameter and distensibility and circulating markers of uraemia …
学术搜索中的文章
J Bellien, C Fréguin-Bouilland, R Joannidès, M Hanoy… - Nephrology Dialysis Transplantation, 2014