作者
Paul Mulder, Virginie Mellin, Julie Favre, Magali Vercauteren, Isabelle Remy-Jouet, Christelle Monteil, Vincent Richard, Sylvanie Renet, Jean Paul Henry, Arco Y Jeng, Randy L Webb, Christian Thuillez
发表日期
2008/9/1
期刊
European heart journal
卷号
29
期号
17
页码范围
2171-2179
出版商
Oxford University Press
简介
Aims
Inhibition of aldosterone synthase, the key enzyme in aldosterone formation, could be an alternative strategy for mineralocorticoid-receptor antagonists in congestive heart failure (CHF), but its effect in CHF is unknown.
Methods and results
We compared, in rats with CHF, the effects of a 7 day and a 12 week treatment with the aldosterone synthase inhibitor FAD286 (4 mg kg−1 day−1) with those induced by spironolactone (80 mg kg−1 day−1). FAD286/spironolactone increased cardiac output without modifying arterial pressure. Long-term FAD286 and spironolactone reduced left ventricular (LV) end-diastolic pressure, LV relaxation constant, and LV dilatation, and these effects were more marked with FAD286, whereas both drugs reduced LV hypertrophy and collagen accumulation to the same extent. Long-term FAD286/spironolactone prevented CHF-related enhancement …
学术搜索中的文章
P Mulder, V Mellin, J Favre, M Vercauteren… - European heart journal, 2008