作者
R Joannidès, C Monteil, BH De Ligny, PF Westeel, M Iacob, E Thervet, S Barbier, J Bellien, Y Lebranchu, SG Seguin, C Thuillez, M Godin, I Etienne
发表日期
2011/11/1
期刊
American Journal of Transplantation
卷号
11
期号
11
页码范围
2414-2422
出版商
Elsevier
简介
Whether or not a cyclosporine A (CsA)-free immunosuppressant regimen based on sirolimus (SRL) prevents aortic stiffening and improves central hemodynamics in renal recipients remains unknown. Forty-four patients (48 ± 2 years) enrolled in the CONCEPT trial were randomized at week 12 (W12) to continue CsA or switch to SRL, both associated with mycophenolate mofetil. Carotid systolic blood pressure (cSBP), pulse pressure (cPP), central pressure wave reflection (augmentation index, AIx) and carotid-to-femoral pulse-wave velocity (PWV: aortic stiffness) were blindly assessed at W12, W26 and W52 together with plasma endothelin-1 (ET-1), thiobarbituric acid-reactive substances (TBARS) and superoxide dismutase (SOD) and catalase erythrocyte activities. At W12, there was no difference between groups. At follow-up, PWV, cSBP, cPP and AIx were lower in the SRL group. The difference in PWV remained …
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R Joannidès, C Monteil, BH De Ligny, PF Westeel… - American Journal of Transplantation, 2011