作者
Michael Parfenov, Chandra Sekhar Pedamallu, Nils Gehlenborg, Samuel S Freeman, Ludmila Danilova, Christopher A Bristow, Semin Lee, Angela G Hadjipanayis, Elena V Ivanova, Matthew D Wilkerson, Alexei Protopopov, Lixing Yang, Sahil Seth, Xingzhi Song, Jiabin Tang, Xiaojia Ren, Jianhua Zhang, Angeliki Pantazi, Netty Santoso, Andrew W Xu, Harshad Mahadeshwar, David A Wheeler, Robert I Haddad, Joonil Jung, Akinyemi I Ojesina, Natalia Issaeva, Wendell G Yarbrough, D Neil Hayes, Jennifer R Grandis, Adel K El-Naggar, Matthew Meyerson, Peter J Park, Lynda Chin, JG Seidman, Peter S Hammerman, Raju Kucherlapati, Cancer Genome Atlas Network
发表日期
2014/10/28
期刊
Proceedings of the National Academy of Sciences
卷号
111
期号
43
页码范围
15544-15549
出版商
National Academy of Sciences
简介
Previous studies have established that a subset of head and neck tumors contains human papillomavirus (HPV) sequences and that HPV-driven head and neck cancers display distinct biological and clinical features. HPV is known to drive cancer by the actions of the E6 and E7 oncoproteins, but the molecular architecture of HPV infection and its interaction with the host genome in head and neck cancers have not been comprehensively described. We profiled a cohort of 279 head and neck cancers with next generation RNA and DNA sequencing and show that 35 (12.5%) tumors displayed evidence of high-risk HPV types 16, 33, or 35. Twenty-five cases had integration of the viral genome into one or more locations in the human genome with statistical enrichment for genic regions. Integrations had a marked impact on the human genome and were associated with alterations in DNA copy number, mRNA transcript …
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M Parfenov, CS Pedamallu, N Gehlenborg… - Proceedings of the National Academy of Sciences, 2014