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Background: Outcomes of repetitive Transcranial Magnetic Stimulation (rTMS) for treatment-resistant depression vary widely across published studies. Several different mood rating scales have been used to assess response and remission.

Objective: To compare the performance of three self-report scales (Inventory of Depressive Symptomatology 30-item [IDS], Patient Health Questionnaire 9-item [PHQ], and Profile of Mood States 30-item [POMS]) and the observer-rated Hamilton Depression Rating Scale 17-item (HDRS) in detecting symptom change during rTMS treatment.

Results: 805 subjects with nonpsychotic MDD completed a six-week course of rTMS treatment with weekly self-report and observer ratings. All scales detected significant improvement during treatment, with correlations of Kendall’s τ= 0.71-0.80 among self-report instruments and τ= 0.52-0.56 between self-report and observer-rated instruments (p …