作者
Jenifer H Voeks, George Howard, Gary S Roubin, Mahmoud B Malas, David J Cohen, W Charles Sternbergh III, Herbert D Aronow, Mark K Eskandari, Alice J Sheffet, Brajesh K Lal, James F Meschia, Thomas G Brott, CREST Investigators
发表日期
2011/12
期刊
Stroke
卷号
42
期号
12
页码范围
3484-3490
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
High stroke event rates among carotid artery stenting (CAS)-treated patients in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) lead-in registry generated an a priori hypothesis that age may modify the relative efficacy of CAS versus carotid endarterectomy (CEA). In the primary CREST report, we previously noted significant effect modification by age. Here we extend this investigation by examining the relative efficacy of the components of the primary end point, the treatment-specific impact of age, and contributors to the increasing risk in CAS-treated patients at older ages.
Methods
Among 2502 CREST patients with high-grade carotid stenosis, proportional hazards models were used to examine the impact of age on the CAS-to-CEA relative efficacy, and the impact of age on risk within CAS-treated and CEA-treated patients.
Results
Age acted as a treatment effect …
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