作者
Virginia J Howard, James F Meschia, Brajesh K Lal, Tanya N Turan, Gary S Roubin, Robert D Brown Jr, Jenifer H Voeks, Kevin M Barrett, Bart M Demaerschalk, John Huston Iii, Ronald M Lazar, Wesley S Moore, Virginia G Wadley, Seemant Chaturvedi, Claudia S Moy, Marc Chimowitz, George Howard, Thomas G Brott
发表日期
2017/10
来源
International journal of stroke
卷号
12
期号
7
页码范围
770-778
出版商
SAGE Publications
简介
Rationale
Trials conducted decades ago demonstrated that carotid endarterectomy by skilled surgeons reduced stroke risk in asymptomatic patients. Developments in carotid stenting and improvements in medical prevention of stroke caused by atherothrombotic disease challenge understanding of the benefits of revascularization.
Aim
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) will test whether carotid endarterectomy or carotid stenting plus contemporary intensive medical therapy is superior to intensive medical therapy alone in the primary prevention of stroke in patients with high-grade asymptomatic carotid stenosis.
Methods and design
CREST-2 is two multicenter randomized trials of revascularization plus intensive medical therapy versus intensive medical therapy alone. One trial randomizes patients to carotid endarterectomy plus intensive medical …
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