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Results

We found urine uromodulin to be correlated with serum creatinine (rho=− 0.43; P< 0.001), bicarbonate (0.20; P< 0.001), and hemoglobin (0.11; P= 0.03) at the time of biopsy but not with urine albumin (− 0.07; P= 0.34). Multivariable models controlling for prebiopsy GFR, serum creatinine at biopsy, and urine albumin showed higher uromodulin to be associated with lower severity of interstitial fibrosis/tubular atrophy and glomerulosclerosis (interstitial fibrosis/tubular atrophy:− 3.5%[95% confidence intervals,− 5.7% to− 1.2%] and glomerulosclerosis:− 3.3%[95% confidence intervals,− 5.9% to− 0.6%] per two-fold difference in uromodulin). However, when both interstitial fibrosis/tubular atrophy and glomerulosclerosis were included in multivariable analysis, only interstitial fibrosis/tubular atrophy was independently associated with uromodulin (interstitial fibrosis/tubular atrophy:− 2.5%[95% confidence intervals,− 4 …