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¹⁸F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of ¹⁸F-THK5351 retention in brain regions thought to contain negligible concentrations of PHF raise questions about the interpretation of the positron emission tomography (PET) signals, particularly given previously described interactions between quinolone derivatives and monoamine oxidase B (MAO-B). Here, we tested the effects of MAO-B inhibition on ¹⁸F-THK5351 brain uptake using PET and autoradiography.

Eight participants (five mild cognitive impairment, two Alzheimer’s disease, and one progressive supranuclear palsy) had baseline ¹⁸F-AZD4694 and ¹⁸F-THK5351 scans in order to quantify brain amyloid and PHF load, respectively. A second ¹⁸F-THK5351 scan was conducted …