作者
Tharick A Pascoal, Monica Shin, Min Su Kang, Mira Chamoun, Daniel Chartrand, Sulantha Mathotaarachchi, Idriss Bennacef, Joseph Therriault, Kok Pin Ng, Robert Hopewell, Reda Bouhachi, Hung-Hsin Hsiao, Andrea L Benedet, Jean-Paul Soucy, Gassan Massarweh, Serge Gauthier, Pedro Rosa-Neto
发表日期
2018/12
期刊
Alzheimer's research & therapy
卷号
10
页码范围
1-14
出版商
BioMed Central
简介
Background
Imaging agents capable of quantifying the brain’s tau aggregates will allow a more precise staging of Alzheimer’s disease (AD). The aim of the present study was to examine the in vitro properties as well as the in vivo kinetics, using gold standard methods, of the novel positron emission tomography (PET) tau imaging agent [18F]MK-6240.
Methods
In vitro properties of [18F]MK-6240 were estimated with autoradiography in postmortem brain tissues of 14 subjects (seven AD patients and seven age-matched controls). In vivo quantification of [18F]MK-6240 binding was performed in 16 subjects (four AD patients, three mild cognitive impairment patients, six healthy elderly individuals, and three healthy young individuals) who underwent 180-min dynamic scans; six subjects had arterial sampling for metabolite correction. Simplified approaches for …
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TA Pascoal, M Shin, MS Kang, M Chamoun… - Alzheimer's research & therapy, 2018