作者
Tharick A Pascoal, Sulantha Mathotaarachchi, Monica Shin, Ah Yeon Park, Sara Mohades, Andrea L Benedet, Min Su Kang, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto, Alzheimer’s Disease Neuroimaging Initiative
发表日期
2018/6
期刊
European journal of nuclear medicine and molecular imaging
卷号
45
页码范围
1021-1030
出版商
Springer Berlin Heidelberg
简介
Purpose
We aimed to determine the amyloid (Aβ) and tau biomarker levels associated with imminent Alzheimer’s disease (AD) - related metabolic decline in cognitively normal individuals.
Methods
A threshold analysis was performed in 120 cognitively normal elderly individuals by modelling 2-year declines in brain glucose metabolism measured with [18F]fluorodeoxyglucose ([18F]FDG) as a function of [18F]florbetapir Aβ positron emission tomography (PET) and cerebrospinal fluid phosphorylated tau biomarker thresholds. Additionally, using a novel voxel-wise analytical framework, we determined the sample sizes needed to test an estimated 25% drugeffect with 80% of power on changes in FDG uptake over 2 years at every brain voxel.
Results
The combination of [18F]florbetapir standardized uptake value ratios and …
学术搜索中的文章
TA Pascoal, S Mathotaarachchi, M Shin, AY Park… - European journal of nuclear medicine and molecular …, 2018