作者
Lucas Porcello Schilling, Eduardo R Zimmer, Monica Shin, Antoine Leuzy, Tharick A Pascoal, Andréa L Benedet, Wyllians Vendramini Borelli, André Palmini, Serge Gauthier, Pedro Rosa-Neto
发表日期
2016
来源
Dementia & neuropsychologia
卷号
10
期号
02
页码范围
79-90
出版商
Associação de Neurologia Cognitiva e do Comportamento
简介
Alzheimer's disease (AD) has been reconceptualised as a dynamic pathophysiological process characterized by preclinical, mild cognitive impairment (MCI), and dementia stages. Positron emission tomography (PET) associated with various molecular imaging agents reveals numerous aspects of dementia pathophysiology, such as brain amyloidosis, tau accumulation, neuroreceptor changes, metabolism abnormalities and neuroinflammation in dementia patients. In the context of a growing shift toward presymptomatic early diagnosis and disease-modifying interventions, PET molecular imaging agents provide an unprecedented means of quantifying the AD pathophysiological process, monitoring disease progression, ascertaining whether therapies engage their respective brain molecular targets, as well as quantifying pharmacological responses. In the present study, we highlight the most important contributions of PET in describing brain molecular abnormalities in AD.
学术搜索中的文章
LP Schilling, ER Zimmer, M Shin, A Leuzy, TA Pascoal… - Dementia & neuropsychologia, 2016