作者
Firoza Z Lussier, Tharick A Pascoal, Mira Chamoun, Joseph Therriault, Cécile Tissot, Mélissa Savard, Min Su Kang, Sulantha Mathotaarachchi, Andrea L Benedet, Marlee Parsons, Muhammad Naveed Iqbal Qureshi, Émilie M Thomas, Monica Shin, Laurie‐Anne Dion, Gassan Massarweh, Jean‐Paul Soucy, I‐Huang Tsai, Paolo Vitali, Zahinoor Ismail, Pedro Rosa‐Neto, Serge Gauthier
发表日期
2020/1
期刊
Alzheimer's & dementia
卷号
16
期号
1
页码范围
192-199
简介
Introduction
Mild behavioral impairment (MBI) is characterized by the emergence of neuropsychiatric symptoms in elderly persons. Here, we examine the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals.
Methods
Ninety‐six cognitively normal elderly individuals underwent MRI, [18F]AZD4694 β‐amyloid‐PET, and [18F]MK6240 tau‐PET. MBI was assessed using the MBI Checklist (MBI‐C). Pearson's correlations and voxel‐based regressions were used to evaluate the relationship between MBI‐C score and [18F]AZD4694 retention, [18F]MK6240 retention, and gray matter (GM) volume.
Results
Pearson correlations revealed a positive relationship between MBI‐C score and global and striatal [18F]AZD4694 standardized uptake value ratios (SUVRs). Voxel‐based regression analyses revealed a positive correlation between MBI‐C score and [18F]AZD4694 …
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FZ Lussier, TA Pascoal, M Chamoun, J Therriault… - Alzheimer's & dementia, 2020