作者
Min Su Kang, Arturo Aliaga Aliaga, Monica Shin, Sulantha Mathotaarachchi, Andrea L Benedet, Tharick A Pascoal, Joseph Therriault, Mira Chamoun, Melissa Savard, Gabriel A Devenyi, Axel Mathieu, M Mallar Chakravarty, Åsa Sandelius, Kaj Blennow, Henrik Zetterberg, Jean-Paul Soucy, A Claudio Cuello, Gassan Massarweh, Serge Gauthier, Pedro Rosa-Neto, Alzheimer’s Disease Neuroimaging Initiative
发表日期
2021/10
期刊
Molecular Psychiatry
卷号
26
期号
10
页码范围
5989-6001
出版商
Nature Publishing Group UK
简介
Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative conditions. However, in Alzheimer’s disease (AD), its reflection on regional neuronal injury in the context of amyloid pathology remains unclear. This study included 83 cognitively normal (CN), 160 mild cognitive impairment (MCI), and 73 AD subjects who were further classified based on amyloid-beta (Aβ) status as positive or negative (Aβ+ vs Aβ−). In addition, 13 rats (5 wild type and 8 McGill-R-Thy1-APP transgenic (Tg)) were examined. In the clinical study, reduced precuneus/posterior cingulate cortex and hippocampal grey matter density were significantly associated with increased NFL concentrations in cerebrospinal fluid (CSF) or plasma in MCI Aβ+ and AD Aβ+. Moreover, AD Aβ+ showed a significant association between the reduced grey matter …
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MS Kang, AA Aliaga, M Shin, S Mathotaarachchi… - Molecular Psychiatry, 2021