作者
Jonathan CW Brooks, Yazhuo Kong, Michael C Lee, Catherine E Warnaby, Vishvarani Wanigasekera, Mark Jenkinson, Irene Tracey
发表日期
2012/5/2
期刊
Journal of Neuroscience
卷号
32
期号
18
页码范围
6231-6239
出版商
Society for Neuroscience
简介
Chronic pain is thought to arise because of maladaptive changes occurring within the peripheral nervous system and CNS. The transition from acute to chronic pain is known to involve the spinal cord . Therefore, to investigate altered human spinal cord function and translate results obtained from other species, a noninvasive neuroimaging technique is desirable. We have investigated the functional response in the cervical spinal cord of 18 healthy human subjects (aged 22–40 years) to noxious thermal and non-noxious tactile stimulation of the left and right forearms. Physiological noise, which is a significant source of signal variability in the spinal cord, was accounted for in the general linear model. Group analysis, performed using a mixed-effects model, revealed distinct regions of activity that were dependent on both the side and the type of stimulation. In particular, thermal stimulation on the medial aspect of the …
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JCW Brooks, Y Kong, MC Lee, CE Warnaby… - Journal of Neuroscience, 2012