作者
Yanfeng Zhang, Qian Yin, Lichen Yin, Liang Ma, Li Tang, Jianjun Cheng
发表日期
2013/6/17
期刊
Angewandte Chemie International Edition
卷号
52
期号
25
页码范围
6435-6439
出版商
WILEY‐VCH Verlag
简介
Design of smart polymeric therapeutics—We designed and synthesized trigger-responsive chain-shattering polymeric therapeutics (CSPTs) via condensation polymerization of a UV-or hydrogen peroxide-responsive domain and a bisfunctional drug as co-monomers. CSPTs have precisely controlled molecular composition and unique chain-shattering type of drug release mechanism. Drug release kinetics can be precisely controlled by means of the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.
学术搜索中的文章
Y Zhang, Q Yin, L Yin, L Ma, L Tang, J Cheng - Angewandte Chemie (International ed. in English), 2013