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Information on knee loading and the relationship between muscle force and tissue response would benefit orthopaedic medicine, the development of engineered tissues, and our understanding of degenerative joint disease. As a step toward developing subject specific musculoskeletal simulations that predict loading on knee structures, this study combines a cadaver-based validated natural multibody knee model with a muscle driven forward dynamics simulation from a subject of similar height and weight for prediction of joint contact mechanics. Geometries for the multibody model were obtained from magnetic resonance images of a cadaver knee. The ligaments were represented with non-linear spring-damper elements with insertions and zero-load lengths derived from experimental measurements. The menisci were represented as discrete elements connected by 6×6 stiffness matrices and to allow …