作者
Hayley T Nicholls, Greg Kowalski, David J Kennedy, Steve Risis, Lee A Zaffino, Nadine Watson, Peter Kanellakis, Matthew J Watt, Alex Bobik, Arend Bonen, Maria Febbraio, Graeme I Lancaster, Mark A Febbraio
发表日期
2011/4/1
期刊
Diabetes
卷号
60
期号
4
页码范围
1100-1110
出版商
American Diabetes Association
简介
OBJECTIVE
The fatty acid translocase and scavenger receptor CD36 is important in the recognition and uptake of lipids. Accordingly, we hypothesized that it plays a role in saturated fatty acid–induced macrophage lipid accumulation and proinflammatory activation.
RESEARCH DESIGN AND METHODS
In vitro, the effect of CD36 inhibition and deletion in lipid-induced macrophage inflammation was assessed using the putative CD36 inhibitor, sulfosuccinimidyl oleate (SSO), and bone marrow–derived macrophages from mice with (CD36KO) or without (wild-type) global deletion of CD36. To investigate whether deletion of macrophage CD36 would improve insulin sensitivity in vivo, wild-type mice were transplanted with bone marrow from CD36KO or wild-type mice and then fed a standard or high-fat diet (HFD) for 20 weeks.
RESULTS
SSO treatment markedly …
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HT Nicholls, G Kowalski, DJ Kennedy, S Risis… - Diabetes, 2011