作者
Vassiliki Tzelepi, Jiexin Zhang, Jing-Fang Lu, Brittany Kleb, Guanglin Wu, Xinhai Wan, Anh Hoang, Eleni Efstathiou, Kanishka Sircar, Nora M Navone, Patricia Troncoso, Shoudan Liang, Christopher J Logothetis, Sankar N Maity, Ana M Aparicio
发表日期
2012/2/1
期刊
Clinical cancer research
卷号
18
期号
3
页码范围
666-677
出版商
American Association for Cancer Research
简介
Purpose: Small-cell prostate carcinoma (SCPC) morphology predicts for a distinct clinical behavior, resistance to androgen ablation, and frequent but short responses to chemotherapy. We sought to develop model systems that reflect human SCPC and can improve our understanding of its biology.
Experimental Design: We developed a set of castration-resistant prostate carcinomas xenografts and examined their fidelity to their human tumors of origin. We compared the expression and genomic profiles of SCPC and large-cell neuroendocrine carcinoma (LCNEC) xenografts to those of typical prostate adenocarcinoma xenografts. Results were validated immunohistochemically in a panel of 60 human tumors.
Results: The reported SCPC and LCNEC xenografts retain high fidelity to their human tumors of origin and are characterized by a marked upregulation of UBE2C and other …
学术搜索中的文章
V Tzelepi, J Zhang, JF Lu, B Kleb, G Wu, X Wan… - Clinical cancer research, 2012