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ABSTRACTObjective To investigate the distributional characteristics of anaphylactogens in prurigo nodularis (PN) patients so as to provide clinical basis for selecting the method of allergy test. Methods We divided 262 PN patients into four groups and then used skin-prick (5 4 patients), skin-patch (5 0 patients), serum IgE allergen detection (56 patients) and serum IgG allergen detection (102 patients) to analyze anaphylactogen positive rate and their distribution differences in PN. Results For skin-prick test in 54 PN patients, the detection rates of platanus orientalis, artemisia argyi, poplar, dust mite, dirt mite, cod, peanut and tomato were higher than those in the control group (P< 0.05). For skin-patch test in 50 PN patients, the detection rates of nickel sulfate, flavor compounds, black rubber, and carba mix were higher than those in the control group (P< 0.05). For serum IgE test in 5 6 PN patients, the detection rates of house dust, scandent hop, cat/dog hair, bug, penicillium/neurospora and mutton were higher than those in the control group (P< 0.05). For serum IgG test in 102 PN ones, the detection rates of crab, shrimp, beef and cod were higher than those in the control group (P< 0.05). Conclusion Skin-prick test and serum IgE detection have high application values in PN patients. Serum IgG detection is of certain importance in adjusting PN patients’ diet structure while skin-patch test applied in PN needs further exploration.