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Detailed depiction of hydrological process and its associated pollution processes plays a critical role in environment improvement and management at basin scale. It also provides a useful tool to assess impact of potential factors on hydrological and water quality conditions. However, it was still difficult to well capture some typical characteristics of these complicated processes including built-in nonlinearity and time-variation, water infrastructure regulations, particularly for highly regulated basins. In this study, an integrated approach of hydrological and water quality dynamic simulation was proposed to solve these difficulties and assess the impacts of several anthropogenic disturbances. The Huai River Basin which was highly disturbed and seriously polluted, was selected as the study area. The main anthropogenic activities considered were point source pollution emissions, diffuse pollutant losses and dam …