作者
NI Medvedev, Victor I Popov, JJ Rodriguez Arellano, Glenn Dallérac, Heather A Davies, Paul L Gabbott, Serge Laroche, IV Kraev, Valérie Doyère, Michael G Stewart
发表日期
2010/2/17
期刊
Neuroscience
卷号
165
期号
4
页码范围
1170-1181
出版商
Pergamon
简介
Long-term morphological synaptic changes associated with homosynaptic long-term potentiation (LTP) and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats were analyzed using three-dimensional (3-D) reconstructions of electron microscope images of ultrathin serial sections from the molecular layer of the dentate gyrus. For the first time in morphological studies, the specificity of the effects of LTP and LTD on both spine and synapse ultrastructure was determined using an N-methyl-d-aspartate (NMDA) receptor antagonist CPP (3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid). There were no differences in synaptic density 24 h after LTP or LTD induction, and CPP alone had no effect on synaptic density. LTP increased significantly the proportion of mushroom spines, whereas LTD increased the proportion of thin spines, and both LTP and LTD decreased stubby spine number. Both …
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NI Medvedev, VI Popov, JJR Arellano, G Dallérac… - Neuroscience, 2010