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The renin-angiotensin system (RAS) is one of major neuro-endocrine entity which is intimately involved in regulating the cellular functions and metabolic activities in the body. The activation of RAS results in the formation and release of angiotensin II mainly as well as angiotensin 1–7 through the participation of angiotensin converting enzyme (ACE) and its homolog ACE2, respectively. Angiotensin II upon activating the angiotensin type 1 receptors (AT₁R) is known to produce a wide variety of effects namely vasoconstriction, fluid retention, fibrosis and thrombosis in addition to promoting oxidative stress, inflammation and hypertrophic process. On the other hand, angiotensin II by activating the angiotensin type 2 receptors (AT₂R) produces effects which are antagonists to those due to AT₁R activation. Furthermore, angiotensin 1–7 has been shown to activate Mas receptors and exert actions which are similar to those …