作者
Jean-Michel Molina, Kathleen Squires, Paul E Sax, Pedro Cahn, Johan Lombaard, Edwin DeJesus, Ming-Tain Lai, Xia Xu, Anthony Rodgers, Lisa Lupinacci, Sushma Kumar, Peter Sklar, Bach-Yen Nguyen, George J Hanna, Carey Hwang, Marcelo Martins, Pedro Enrique Cahn, Gustavo D Lopardo, Norma Porteiro, Mark Theo Bloch, David Alfred Baker, Norman Roth, Richard James Moore, Robert James Finlayson, James McMahon, Armin Rieger, Alexander Zoufaly, Sylvia Hartl, Robert Zangerle, Fiona Smaill, Sharon L Walmsley, Brian Conway, Anita Rachlis, Graham HR Smith, Carlos Perez, Alejandro Afani, Maria Isabel E Campos Barker, Carolina Eugenia Chahin, Marcelo Wolff Reyes, Jan Gerstoft, Nina Weis, Alex Lund Laursen, Yazdan Yazdanpanah, Laurent Cotte, Francois Raffi, Philippe Morlat, Pierre-Marie Girard, Christine Katlama, Juergen K Rockstroh, Keikawus Arasteh, Stefan Esser, Albrecht Stoehr, Hans-Juergen Stellbrink, Matthias Stoll, Dirk Schuermann, Gerd Faetkenheuer, Johannes Bogner, Thomas Lutz, Axel Baumgarten, Hans Jaeger, Andrea Gori, Gabriel Coltan, Felicia Constandis, Simona Manuela Erscoiu, Liviu-Jany Prisacariu, Sorin Rugina, Adrian Streinu-Cercel, Vadim Valentinovich Pokrovsky, Natalia V Zakharova, Andrey Anatolyevich Shuldyakov, Elena Pavlovna Ryamova, Valeriy Viktorovich Kulagin, Olga Aleksandrovna Tsybakova, Elena Orlova-Morozova, Firaya Nagimova, Evgeniy Voronin, Tatyana Evgenyevna Shimonova, Oleg Anatolyevich Kozyrev, Catherine Orrell, Johannes Jurgens Lombaard, Margaretha Elizabeth Botes, Joaquin Portilla, Josep Maria Gatell, Maria Jesus Perez, Jose Ramon Arribas, Eugenia Negredo, Daniel Podzamczer, Federico Pulido, Jesus Troya, Ignacio De los Santos, Juan Berenguer, Ian G Williams, Margaret A Johnson, Gabriel Schembri, Amanda Clarke, Mark Gompels, Julie Meriel Fox, Steven John Taylor, Stephen Kegg, Debbie P Hagins, Olayemi O Osiyemi, David James Prelutsky, Moti N Ramgopal, Robin Dretler, Louis Sloan, Stanley T Lewis, Patrick G Clay, Nicholaos C Bellos, Melanie A Thompson, Jose Montero, Cheryl K McDonald, Catherine Creticos, David Shamblaw, Antonio E Terrelonge, Martin Valdes, Karen T Tashima, William J Robbins, Franco Antonio Felizarta, Richard A Elion, Jihad Slim, Jacob Paul Lalezari, Sujata N Lalla-Reddy, Peter Jerome Ruane, Anthony Mills, Jerry L Cade, Rafael E Campo, Craig A Dietz, Gary Blick, Cynthia Mayer, Juan Carlos Rondon, Paul P Cook, Eric Daar, Princy N Kumar, Susan Swindells, Jose Guillermo Castro, Javier O Morales-Ramirez, Lizette Santiago, Jorge L Santana-Bagur
发表日期
2018/5/1
期刊
The lancet HIV
卷号
5
期号
5
页码范围
e211-e220
出版商
Elsevier
简介
Background
Doravirine is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with a pharmacokinetic profile supporting once-daily dosing, and potent in-vitro activity against the most common NNRTI-resistant HIV-1 variants. We compared doravirine with ritonavir-boosted darunavir, when both were given with two nucleoside reverse transcriptase inhibitors (NRTIs), in adults with previously untreated HIV-1 infection.
Methods
In this randomised, controlled, double-blind, multicentre, non-inferiority trial, adults with HIV-1 infection were screened and enrolled at 125 clinical centres in 15 countries. Eligible participants (aged ≥18 years) were naive to antiretroviral therapy with plasma HIV-1 RNA of at least 1000 copies per mL at screening. Participants who had previously been treated for a viral infection other than HIV-1, those taking immunosuppressive drugs, and individuals with active acute hepatitis were …
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