作者
Natalia Soriano-Sarabia, Alejandro Vallejo, Reposo Ramírez-Lorca, María del Mar Rodríguez, Ana Salinas, Ildefonso Pulido, María E Sáez, Manuel Leal
发表日期
2008/10/1
期刊
JAIDS Journal of Acquired Immune Deficiency Syndromes
卷号
49
期号
2
页码范围
128-135
出版商
LWW
简介
Objective:
To analyze the influence of single-nucleotide polymorphisms (SNPs) in TLR2 (1892A/C and 2258G/A), TLR4 (896A/G and 1196C/T), and TLR9 (1635A/G) genes on CD4 count, HIV viral load, and clinical progression in a cohort of naive HIV-infected patients.
Methods:
TLR2, TLR4, and TLR9 SNPs were analyzed in 369 naive HIV-infected patients by real-time polymerase chain reaction and melting curve technology. TLR2 1892C/A and TLR9 1635A/G SNPs were also analyzed in a non-HIV-infected population. Multivariate multiple regression analysis and Cox regression analyses were performed to assess the potential association between the SNPs and the end points.
Results:
TLR2 and TLR4 SNPs were not associated with the end points of the study. Regarding TLR9 1635A/G SNP, patients with the AA genotype showed statistically lower CD4 count (P= 0.003) and higher HIV viral load (P= 0.0018 …
学术搜索中的文章
N Soriano-Sarabia, A Vallejo, R Ramírez-Lorca… - JAIDS Journal of Acquired Immune Deficiency …, 2008