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To investigate differences in the age‐related decline in brain tissue concentration between Masters athletes and sedentary older adults.

Twelve Masters athletes (MA) (three females, age = 72.4 ± 5.6 years, endurance training >15 years), 12 sedentary elderly (SE) similar in age and educational level (four females, age = 74.6 ± 4.3 years), and nine young controls (YC) (four females, age = 27.2 ± 3.6 years) participated. T1‐weighted high‐resolution (1 × 1 × 1mm³) images were acquired. Voxel‐based analysis was conducted to identify clusters showing tissue concentration differences with t‐tests. Cognitive function was assessed using a standard clinical battery focused on executive function and memory.

Two MA and two SE were unable to complete the magnetic resonance imaging (MRI) study. Both SE and MA showed lower gray matter (GM) concentrations than YC in the …