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Changes in functional GABA_AR signaling in hippocampus have previously been evaluated using pre-clinical animal models of either diffuse brain injury or extreme focal brain injury that precludes measurement of cells located ipsilateral to injury. As a result, there is little information about the status of functional GABA_AR signaling in dentate granule cells (DGCs) located ipsilateral to focal brain injury, where significant cellular changes have been documented. We used whole-cell patch-clamp recordings from hippocampal slices to measure changes in GABA_ARs in dentate granule cells (DGCs) at 1–2, 3–5, and 8–13 weeks after controlled cortical impact (CCI) brain injury. Synaptic and tonic GABA_AR currents (I_TonicGABA) were measured in DGCs at baseline conditions and during application of the GABA_AR agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol hydrochloride (THIP) to assess in the function of δ …