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In contrast to the conventional minimum mean square error (MMSE)-based noise reduction techniques, we propose a supervised method to enhance speech by means of finding a mapping function between noisy and clean speech signals based on deep neural networks (DNNs). In order to be able to handle a wide range of additive noises in real-world situations, a large training set that encompasses many possible combinations of speech and noise types, is first designed. A DNN architecture is then employed as a nonlinear regression function to ensure a powerful modeling capability. Several techniques have also been proposed to improve the DNN-based speech enhancement system, including global variance equalization to alleviate the over-smoothing problem of the regression model, and the dropout and noise-aware training strategies to further improve the generalization capability of DNNs to unseen …