作者
Keerti Jain, Ashwni Kumar Verma, Prabhat Ranjan Mishra, Narendra Kumar Jain
发表日期
2015/4/1
期刊
Nanomedicine: Nanotechnology, Biology and Medicine
卷号
11
期号
3
页码范围
705-713
出版商
Elsevier
简介
This paper describes a novel strategy for targeted delivery of amphotericin B (AmB) to macrophages with muramyl dipeptide (MDP) conjugated multimeric poly(propyleneimine) (PPI) dendrimers. Synergistic antiparasitic activity due to immunostimulation by multimeric presentation of MDP on dendrimers was anticipated. MDP conjugated 5.0G PPI (MdPPI) dendrimers were synthesized and characterized. Therapeutic activity and toxicity of dendrimeric formulation of AmB (MdPPIA) were compared with marketed formulations of AmB. Highly significant (P < 0.01) reduction in toxicity was observed in hemolytic toxicity and cytotoxicity studies in erythrocytes and J774A.1 macrophage cells, respectively. Formulation MdPPIA showed appreciable macrophage targeting potential and higher or equivalent antiparasitic activity against parasite infected macrophage cell lines and in vivo infection in Balb/c mice. These results …
学术搜索中的文章
K Jain, AK Verma, PR Mishra, NK Jain - Nanomedicine: Nanotechnology, Biology and Medicine, 2015