作者
Suyeon Kang, Jeong Yee, Jae Youn Kim, Hye Won Han, Sang Oh Kang, Kyung Eun Lee, Hye Sun Gwak
发表日期
2020/12/1
期刊
Therapeutic drug monitoring
卷号
42
期号
6
页码范围
866-871
出版商
LWW
简介
Background:
Serum concentrations of voriconazole are difficult to predict, especially in pediatric patients, because of its complex pharmacokinetic characteristics. This study aimed to identify the factors associated with the concentration of voriconazole in pediatric patients.
Methods:
This cohort study was based on retrospective data collection and involved the administration of voriconazole to pediatric patients younger than 18 years, between January 2010 and August 2017. Electronic medical records of the patients were reviewed to collect demographic characteristics, voriconazole treatment regimen, and factors that could potentially influence voriconazole trough concentrations. A voriconazole trough serum concentration of less than 1.0 mcg/mL or greater than 5.5 mcg/mL was defined as outside the therapeutic range and was set as the outcome of this study.
Results:
Among the 114 patients enrolled, 61 patients were …
引用总数
20212022202320244241
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