作者
Carole Planchette, Heinz Pichler, Miriam Wimmer-Teubenbacher, Michael Gruber, Heidrun Gruber-Wölfler, Stefan Mohr, Caroline Tetyczka, W-K Hsiao, Amrit Paudel, Eva Roblegg, Johannes Khinast
发表日期
2016/7/25
期刊
International journal of pharmaceutics
卷号
509
期号
1-2
页码范围
518-527
出版商
Elsevier
简介
We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a non-contact printing system that incorporates both piezoelectric- and solenoid valve-based inkjet printing technologies, to deliver both active and inactive pharmaceutical materials onto medical-graded orodispersible films. By using two complimentary inkjet technologies, we were able to dispense an extensive range of fluids, from aqueous drug solutions to viscous polymer coating materials. Essentially, we demonstrate printing of a wide range of formulations for patient-ready, orodispersible drug dosage forms, without the risk of drug degradation by ink heating and of substrate damages (by contact printing). In addition, our printing process has been optimized to ensure that the drug doses can be loaded onto the orally dissolvable films without introducing defects, such as holes or …
引用总数
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