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Establishment of common methods is an advantage for comparability of studies. We have read the insightful Correspondence in EJHG in which Veitia addresses the performance of two recently published formulas for transforming intensity signals from SNP-array data of mosaic loss of chromosome Y (LOY) into the percentage of cells with LOY in a sample. Acquired loss of chromosome Y is the most common somatic mutation in human blood cells [1–8] and affected men have an increased risk for allcause mortality [1, 5]. Furthermore, LOY in blood has been found to be associated with risk for various human disease such as hematological and non-hematological cancers, autoimmune conditions, Alzheimer, s disease, cardiovascular diseases, schizophrenia, diabetes, and age-related macular degeneration [1–3, 5, 8](and references therein). In addition to age, replicated risk factors associated with LOY in blood …