作者
Barbara Olasov Rothbaum, Matthew Price, Tanja Jovanovic, Seth D Norrholm, Maryrose Gerardi, Boadie Dunlop, Michael Davis, Bekh Bradley, Erica J Duncan, Albert Rizzo, Kerry J Ressler
发表日期
2014/6
期刊
American Journal of Psychiatry
卷号
171
期号
6
页码范围
640-648
出版商
American Psychiatric Association
简介
Objective
The authors examined the effectiveness of virtual reality exposure augmented with d-cycloserine or alprazolam, compared with placebo, in reducing posttraumatic stress disorder (PTSD) due to military trauma.
Method
After an introductory session, five sessions of virtual reality exposure were augmented with d-cycloserine (50 mg) or alprazolam (0.25 mg) in a double-blind, placebo-controlled randomized clinical trial for 156 Iraq and Afghanistan war veterans with PTSD.
Results
PTSD symptoms significantly improved from pre- to posttreatment across all conditions and were maintained at 3, 6, and 12 months. There were no overall differences in symptoms between d-cycloserine and placebo at any time. Alprazolam and placebo differed significantly on the Clinician-Administered PTSD Scale score at posttreatment and PTSD diagnosis at 3 months posttreatment; the alprazolam group showed a higher rate of …
学术搜索中的文章
BO Rothbaum, M Price, T Jovanovic, SD Norrholm… - American Journal of Psychiatry, 2014