查看文章

Objective:

Data suggests that lower serum chloride (Cl-) is associated with higher mortality and cardiovascular risk in populations with hypertension or heart failure. In this study, we tested the association between serum Cl-and cardiovascular outcomes in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Blood Pressure-Lowering Arm.

Design and method:

The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) randomized a subset of 6549 patients at risk with no history of coronary heart disease to either atenolol-based or amlodipine-based BP lowering treatment and followed-up for 5.5 years. Serum Cl-was measured at baseline in 319 participants who had a cardiovascular event and 1361 controls, matched for age and sex. The primary outcome was a composite of fatal and non-fatal myocardial infarction, stroke and heart failure. Subjects were grouped into four categories based on Serum Cl-levels (Cl …