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The bacterial membrane lipid-based continental paleothermometer, the MBT/CBT or MBT′–CBT proxy (methylation index of branched tetraethers/cyclization of branched tetraethers), results in a large temperature deviation when applied in semiarid and arid regions. Here we propose new calibration models based on the investigation of >100 surface soils across a large climatic gradient, with a particular focus on semiarid and arid regions of China, and apply them to a loess–paleosol sequence. As reported elsewhere, MBT values exhibit a much higher correlation with MAAT than with summer temperature, suggesting a minimal seasonality bias; however, MBT is apparently insensitive to temperature <5 °C or >20 °C. Additional complexities are apparent in alkaline and arid soils, which are characterized by different relationships to climatic parameters than those in the complete Chinese (or global) dataset. For …