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Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels. CIL is used in combination with other drugs like Telmisartan, Olmesartan Medoxomil. CIL has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, High-performance liquid Chromatography with ultraviolet detection, liquid chromatography coupled with tandem mass spectrometry, densitometry. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.