作者
Anne‐Marie Chang, Nayantara Santhi, Melissa St Hilaire, Claude Gronfier, Dayna S Bradstreet, Jeanne F Duffy, Steven W Lockley, Richard E Kronauer, Charles A Czeisler
发表日期
2012/7/1
期刊
The Journal of physiology
卷号
590
期号
13
页码范围
3103-3112
出版商
Blackwell Publishing Ltd
简介
Key points
  • • 
    Light is the strongest time cue for entrainment and phase resetting of the circadian clock.
  • • 
    In humans, exposure to long‐duration light (6.5 h) in the late evening/early night causes phase delays, suppresses melatonin and increases alertness.
  • • 
    Here we studied the effects of different durations of exposure to a single high‐intensity (∼10,000 lux) light pulse (0.2 h, 1 h, 2.5 h and 4.0 h) on phase shifting, suppression of melatonin and self‐reported sleepiness in young men and women.
  • • 
    Phase‐resetting and melatonin‐suppression responses were dose dependent and non‐linear; shorter light exposures more efficiently phase‐shift the clock, suppress melatonin and induce alertness.
Abstract  Light exposure in the early night induces phase delays of the circadian rhythm in melatonin in humans. Previous studies have investigated the effect of timing, intensity, wavelength, history and pattern of light …
引用总数
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学术搜索中的文章
AM Chang, N Santhi, M St Hilaire, C Gronfier… - The Journal of physiology, 2012