作者
Manuel Garcia-Käufer, Tarek Haddad, Marlies Bergheim, Richard Gminski, Preeti Gupta, Nupur Mathur, Klaus Kümmerer, Volker Mersch-Sundermann
发表日期
2012/6
期刊
Environmental Science and Pollution Research
卷号
19
页码范围
1719-1727
出版商
Springer-Verlag
简介
Purpose
Ciprofloxacin (CIP), a broad-spectrum, second-generation fluoroquinolone, has frequently been found in hospital wastewaters and effluents of sewage treatment plants. CIP is scarcely biodegradable, has toxic effects on microorganisms and is photosensitive. The aim of this study was to assess the genotoxic potential of CIP in human HepG2 liver cells during photolysis.
Methods
Photolysis of CIP was performed in aqueous solution by irradiation with an Hg lamp, and transformation products were monitored by HPLC-MS/MS and by the determination of dissolved organic carbon (DOC). The cytotoxicity and genotoxicity of CIP and of the irradiated samples were determined after 24 h of exposure using the WST-1 assay and the in vitro micronucleus (MN) test in HepG2 cells.
Results
The concentration of CIP …
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M Garcia-Käufer, T Haddad, M Bergheim, R Gminski… - Environmental Science and Pollution Research, 2012