作者
Christopher C Rowe, Kathryn A Ellis, Miroslava Rimajova, Pierrick Bourgeat, Kerryn E Pike, Gareth Jones, Jurgen Fripp, Henri Tochon-Danguy, Laurence Morandeau, Graeme O'Keefe, Roger Price, Parnesh Raniga, Peter Robins, Oscar Acosta, Nat Lenzo, Cassandra Szoeke, Olivier Salvado, Richard Head, Ralph Martins, Colin L Masters, David Ames, Victor L Villemagne
发表日期
2010/8/1
期刊
Neurobiology of aging
卷号
31
期号
8
页码范围
1275-1283
出版商
Elsevier
简介
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), recruited 1112 participants for a longitudinal study of aging. Of these, 287 had 11C-PiB-positron emission tomography (PET) and magnetic resonance imaging (MRI) at study entry. One hundred seventy-seven healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients were imaged. Controlled selection of HC ensured inclusion of very elderly, approximately 50% with subjective memory complaints (SMC) and 50% with an ApoE-ε4 allele. High PiB binding was present in 49% of HC carrying at least 1 ApoE-ε4 allele versus 21% of HC noncarriers (33% of HC overall). PiB binding increased linearly with age, most strongly in ε4 carriers. Subjective memory complaints was only associated with elevated PiB …
引用总数
学术搜索中的文章
CC Rowe, KA Ellis, M Rimajova, P Bourgeat, KE Pike… - Neurobiology of aging, 2010