作者
Zhong-Huang Wang, Qiang-Hui Zhu, Xin Li, Jun-Wei Zhu, Dong-Mei Tian, Si-Si Zhang, Hai-Long Kang, Cui-Ping Li, Li-Li Dong, Wen-Ming Zhao, Meng-Hua Li
发表日期
2021/8/17
期刊
Frontiers in Genetics
卷号
12
页码范围
714852
出版商
Frontiers Media SA
简介
Sheep (Ovis aries), one of the main and oldest livestock in the world, are particularly beneficial to human society by supplying wool, meat, milk, and skins. They have been domesticated ca. 8,000–12,000 years BP (Zeder, 2008). Being one of the earliest domesticated animals and one of the closest animals to human, sheep are also useful in revealing the history of early human settlements and expansions by analyzing their patterns of genetic variants (Zhao et al., 2017; Hu et al., 2019a; Deng et al., 2020).
The completion of a sheep reference genome (Jiang et al., 2014) and rapid advancement in highthroughput sequencing technologies have greatly accelerated the understanding of domestication, evolution and genetic mechanisms underlying various phenotypic traits in sheep (Lv et al., 2014; Yang et al., 2016; Alberto et al., 2018; Naval-Sanchez et al., 2018; Li et al., 2020). With the amount of increasing genomic data, establishing a systematic database in sheep for data archiving, analyzing and visualization becomes particularly essential, since so far only few databases are available for sheep compared with a variety of integrated resources established in mice (Laulederkind et al., 2013), dogs (Tang et al., 2019) and cattle (Elsik et al., 2016). To date, one of the most widely accessible genetic databases for sheep is the International Sheep Genomics Consortium (ISGC, https://www. sheephapmap. org/). The ISGC database contains sheep genome assemblies and variants of 935 sheep representing 69 breeds from 21 countries. The ISGC database consists of around 50 million filtered variants called using GATK and Samtools programs based on …
引用总数
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ZH Wang, QH Zhu, X Li, JW Zhu, DM Tian, SS Zhang… - Frontiers in Genetics, 2021