作者
Ann Hellström, David Ley, Ingrid Hansen‐Pupp, Boubou Hallberg, Chatarina Löfqvist, Linda Van Marter, Mirjam Van Weissenbruch, Luca A Ramenghi, Kathryn Beardsall, David Dunger, Anna‐Lena Hård, Lois EH Smith
发表日期
2016/6
来源
Acta paediatrica
卷号
105
期号
6
页码范围
576-586
简介
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin‐like growth factor 1 (IGF‐1) axis is the major hormonal mediator of growth in utero, and levels of IGF‐1 are often very low after preterm birth. We reviewed the role of IGF‐1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF‐1 deficiency in preterm morbidities.
Conclusion
There is a rationale for clinical trials to evaluate the potential benefits of IGF‐1 replacement in very preterm infants.
学术搜索中的文章
A Hellström, D Ley, I Hansen‐Pupp, B Hallberg… - Acta paediatrica, 2016