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Background: Sertoli cell tight junctions (TJs) are gonadotropin-dependent components of the blood-testis barrier (BTB) that sequesters adluminal meiotic and post-meiotic germ cells from the testicular vasculature. In normal adult rodents and men, the key TJ transmembrane protein, claudin-11, is localized to the TJ at the BTB. In rodents following gonadotropin suppression and associated germ cell loss, claudin-11 is spatially disrupted, and TJ function is lost. The potential for the human TJ to be gonadotropin-dependent has not been elucidated. Aim(s): To investigate the localization of claudin-11 at the human TJ following chronic gonadotropin suppression. Method(s): Claudin-11 was assessed by immunohistochemistry in archived testis tissue from men following 8 weeks of gonadotropin suppression and for whom meiotic and post-meiotic germ cell numbers were available. Suppression regimens were i …