作者
William M Switzer, Shaohua Tang, Steve Ahuka-Mundeke, Anupama Shankar, Debra L Hanson, HaoQiang Zheng, Ahidjo Ayouba, Nathan D Wolfe, Matthew LeBreton, Cyrille F Djoko, Ubald Tamoufe, Amandine Esteban, Walid Heneine, Martine Peeters, Linda L Wright, Jean Jacques Muyembe-Tamfum, Emile Okitolonda Wemakoy, Prime Mulembakani, Nicole A Hoff, Anne W Rimoin
发表日期
2012/12
期刊
Retrovirology
卷号
9
页码范围
1-15
出版商
BioMed Central
简介
Background
Zoonotic transmission of simian retroviruses in Central Africa is ongoing and can result in pandemic human infection. While simian foamy virus (SFV) infection was reported in primate hunters in Cameroon and Gabon, little is known about the distribution of SFV in Africa and whether human-to-human transmission and disease occur. We screened 3,334 plasmas from persons living in rural villages in central Democratic Republic of Congo (DRC) using SFV-specific EIA and Western blot (WB) tests. PCR amplification of SFV polymerase sequences from DNA extracted from buffy coats was used to measure proviral loads. Phylogenetic analysis was used to define the NHP species origin of SFV. Participants completed questionnaires to capture NHP exposure information.
Results
Sixteen (0.5%) samples were WB-positive; 12 of 16 were from …
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WM Switzer, S Tang, S Ahuka-Mundeke, A Shankar… - Retrovirology, 2012
