作者
Hasan Hüseyin Tavukçu, Tarik Emre Şener, İlker Tinay, Cem Akbal, Mehmet Erşahin, Özge Çevik, Selin Çadırcı, Russel J Reiter, Göksel Şener
发表日期
2014/4
期刊
Clinical and Experimental Pharmacology and Physiology
卷号
41
期号
4
页码范围
309-316
简介
- Oxidative stress plays an important role both in spinal cord injury (SCI) and erectile dysfunction (ED). The present study investigated the effects of melatonin and tadalafil treatment alone or in combination on SCI‐induced ED.
- Male Wistar albino rats (n = 40) were divided into five groups: sham‐operated control and SCI‐injured rats given either vehicle, melatonin (10 mg/kg, i.p.), tadalafil (10 mg/kg, p.o.) or a combination of melatonin and tadalafil. Spinal cord injury was induced using a standard weight‐drop method. On Day 7 after SCI, intracavernosal pressure (ICP) was measured and all rats were decapitated. Cavernosal tissues were obtained to examine caspase 3, nitric oxide synthase (NOS), myeloperoxidase (MPO) and superoxide dismutase (SOD) activities, as well as cGMP, nerve growth factor (NGF), malondialdehyde (MDA) and glutathione (GSH) levels.
- Spinal cord injury caused oxidative damage, as …
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HH Tavukçu, TE Şener, İ Tinay, C Akbal, M Erşahin… - Clinical and Experimental Pharmacology and …, 2014