作者
Kenneth Oben Eyong, Harquin Simplice Foyet, Guerisson Baïrys, Gabriel Ngosong Folefoc, Emanuel Acha Asongalem, Andreas Lagojda, Marc Lamshöft
发表日期
2015/11/4
期刊
Journal of ethnopharmacology
卷号
174
页码范围
277-286
出版商
Elsevier
简介
Objective
Vitellaria paradoxa (shea tree) is used in traditional medicine for the treatment of various ailments, including, inflammation and fever. Therefore the present research investigates the anti-inflammatory and anti-rheumatic effects of V. paradoxa stem bark extracts in rats and the isolation and characterization of its active constituents.
Methods
The anti-inflammatory activity of ethyl acetate extract of V. Paradoxa (VPEE) was evaluated by use of the carrageenan-induced paw oedema model in rats. Moreover, rheumatoid arthritis (RA) was induced by injection of Freund's Completed Adjuvant (FCA) into the subplantar surface of the hind paw of the male Wistar rats. Paw volume was measured plethysmometrically. Joint swelling was measured using electronic vernier caliper. Hot plate test was used to assess the effect of VPEE on hyperalgesia while open field was used to assess the locomotors activity. The relative …
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KO Eyong, HS Foyet, G Baïrys, GN Folefoc… - Journal of ethnopharmacology, 2015