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To pathologically verify the correlation between native T₁ mapping, postcontrast T₁ mapping, and extracellular volume fraction (ECV) and myocardial diffuse fibrosis, as determined by collagen volume fraction (CVF).

Thirty New Zealand white rabbits were randomly divided into the control group (n = 6), diabetes 3 months group (n = 8), diabetes 6 months group (n = 8), and diabetes 9 months group (n = 8). All the rabbits underwent clinical 3.0T magnetic resonance (MR) examinations with pre‐ and postcontrast modified Look–Locker inversion recovery T₁ mapping. For the histological study, each rabbit was sacrificed after MR scanning, hematoxylin and eosin and Masson staining of the left ventricular myocardium were performed, and CVF was calculated. Pre‐ and postcontrast T₁ values and ECV were compared to CVF using Pearson's correlation coefficients.

Two rabbits …