作者
Vlastimil Sulc, Samantha Stykel, Dennis P Hanson, Benjamin H Brinkmann, David T Jones, David R Holmes III, Richard A Robb, Matthew L Senjem, Brian P Mullan, Robert E Watson Jr, Daniel Horinek, Gregory D Cascino, Lily C Wong-Kisiel, Jeffrey W Britton, Elson L So, Gregory A Worrell
发表日期
2014/3/18
期刊
Neurology
卷号
82
期号
11
页码范围
932-939
出版商
Lippincott Williams & Wilkins
简介
Objective
To evaluate the benefit of statistical SPECT processing over traditional subtraction methods, we compared ictal–interictal SPECT analyzed by statistical parametric mapping (SPM) (ISAS), statistical ictal SPECT coregistered to MRI (STATISCOM), and subtraction ictal–interictal SPECT coregistered with MRI (SISCOM) in patients with MRI-negative focal temporal lobe epilepsy (nTLE) and extratemporal lobe epilepsy (nETLE).
Methods
We retrospectively identified 49 consecutive cases of drug-resistant focal epilepsy that had a negative preoperative MRI and underwent interictal and ictal SPECT prior to resective epilepsy surgery. Interictal and ictal SPECT scans were analyzed using SISCOM, ISAS, and STATISCOM to create hyperperfusion and hypoperfusion maps for each patient. Reviewers blinded to clinical data and the SPECT analysis method marked the site of probable seizure origin and indicated their …
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V Sulc, S Stykel, DP Hanson, BH Brinkmann, DT Jones… - Neurology, 2014