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In the year 2000, it is estimated that over 20,000 men underwent transperineal interstitial permanent prostate brachytherapy (TIPPB) for treatment of prostate cancer. Trans-urethral ultrasound (TUUS) is a new interactive, real-time 3D imaging method that may be effective in therapy-guidance during and after TIPPB. TUUS provides higher resolution than trans-rectal ultrasound (TRUS). TUUS can be used to accurately localize radioactive seeds and therefore contribute to more accurate determination of radiation dose distribution throughout the tissue after the completion of the procedure, similar to information currently provided by expensive and offline CT scans. A TUUS catheter can be used to acquire 2D section images or 3D volume images for detailed analyses of the prostate and associated tissue. Initial development of TUUS imaging was carried out on an ultrasound-equivalent prostate phantom with cylindrical …