作者
Robert E Schoen, Paul F Pinsky, Joel L Weissfeld, Lance A Yokochi, Timothy Church, Adeyinka O Laiyemo, Robert Bresalier, Gerald L Andriole, Saundra S Buys, E David Crawford, Mona N Fouad, Claudine Isaacs, Christine C Johnson, Douglas J Reding, Barbara O'Brien, Danielle M Carrick, Patrick Wright, Thomas L Riley, Mark P Purdue, Grant Izmirlian, Barnett S Kramer, Anthony B Miller, John K Gohagan, Philip C Prorok, Christine D Berg
发表日期
2012/6/21
期刊
New England Journal of Medicine
卷号
366
期号
25
页码范围
2345-2357
出版商
Massachusetts Medical Society
简介
Background
The benefits of endoscopic testing for colorectal-cancer screening are uncertain. We evaluated the effect of screening with flexible sigmoidoscopy on colorectal-cancer incidence and mortality.
Methods
From 1993 through 2001, we randomly assigned 154,900 men and women 55 to 74 years of age either to screening with flexible sigmoidoscopy, with a repeat screening at 3 or 5 years, or to usual care. Cases of colorectal cancer and deaths from the disease were ascertained.
Results
Of the 77,445 participants randomly assigned to screening (intervention group), 83.5% underwent baseline flexible sigmoidoscopy and 54.0% were screened at 3 or 5 years. The incidence of colorectal cancer after a median follow-up of 11.9 years was 11.9 cases per 10,000 person-years in the intervention group (1012 cases), as compared with 15.2 cases per 10,000 person-years in the usual-care group (1287 cases …
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RE Schoen, PF Pinsky, JL Weissfeld, LA Yokochi… - New England Journal of Medicine, 2012