作者
Susan V Lynch, Robert A Wood, Homer Boushey, Leonard B Bacharier, Gordon R Bloomberg, Meyer Kattan, George T O’Connor, Megan T Sandel, Agustin Calatroni, Elizabeth Matsui, Christine C Johnson, Henry Lynn, Cynthia M Visness, Katy F Jaffee, Peter J Gergen, Diane R Gold, Rosalind J Wright, Kei Fujimura, Marcus Rauch, William W Busse, James E Gern
发表日期
2014/9/1
期刊
Journal of Allergy and Clinical Immunology
卷号
134
期号
3
页码范围
593-601. e12
出版商
Mosby
简介
Background
Wheezing illnesses cause major morbidity in infants and are frequent precursors to asthma.
Objective
We sought to examine environmental factors associated with recurrent wheezing in inner-city environments.
Methods
The Urban Environment and Childhood Asthma study examined a birth cohort at high risk for asthma (n = 560) in Baltimore, Boston, New York, and St Louis. Environmental assessments included allergen exposure and, in a nested case-control study of 104 children, the bacterial content of house dust collected in the first year of life. Associations were determined among environmental factors, aeroallergen sensitization, and recurrent wheezing at age 3 years.
Results
Cumulative allergen exposure over the first 3 years was associated with allergic sensitization, and sensitization at age 3 years was related to recurrent wheeze. In contrast, first-year exposure to cockroach, mouse, and cat …
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SV Lynch, RA Wood, H Boushey, LB Bacharier… - Journal of Allergy and Clinical Immunology, 2014